Endometrial spatio-temporal image correlation (STIC) and prediction of outcome following assisted reproductive treatment. (August 2016)

• Record Type: Journal Article
• Authors: Polanski, Lukasz T.; Baumgarten, Miriam N.; Brosens, Jan; Quenby, Siobhan; Campbell, Bruce; Martins, Wellington; Raine-Fenning, Nick
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 203(2016:Aug.)
• Page Start: 320
• Page End: 325
• Publication Date: 2016-08
• Subjects: Spatio-temporal image correlation (STIC) -- 3D ultrasound -- Three-dimensional power Doppler -- In vitro fertilization (IVF); Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2016.06.015
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Objective: The aim of this study was to correlate manual and spherical endometrial spatio-temporal image correlation (STIC) vascularity indices with assisted reproductive treatment (ART) outcomes. Study design: STIC ultrasound assessments of the endometrium were carried out at three time-points in 127 women in a prospective observational study. Results: Biochemical pregnancy rate was 69% (88/127), with a biochemical and clinical pregnancy loss of 17%. Endometrial STIC vascularity indices in the assessed time-points did not differ between subjects who achieved a clinical pregnancy and those who did not ( P > 0.05). For first trimester miscarriage, minimal manual vascularization index (VI) at oocyte collection (cut-off value ≥0.7; sensitivity 80.0% and specificity 68.1%) demonstrated the highest area under the curve (AUC) of 0.8. Conclusion: In summary, STIC modality is not a useful tool to predict ART outcome, however manual STIC analysis of endometrial vascularity seems to be more accurate in predicting first trimester pregnancy loss.