Saponins of Agave: Chemistry and bioactivity. (October 2016)

• Record Type: Journal Article
• Authors: Sidana, Jasmeen; Singh, Bikram; Sharma, Om P.
• Is Part Of: Phytochemistry. Volume 130(2016:Oct.)
• Page Start: 22
• Page End: 46
• Publication Date: 2016-10
• Subjects: Agave -- Agavaceae -- Saponins -- Sapogenins -- Spirostanol glycosides -- Furostanol glycosides; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2016.06.010
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: The genus Agave comprises more than 400 species with geographical presence in the tropical and sub-tropical regions of the world. These plants have a rich history of folkloric use and are known for a wide spectrum of applications. Secondary metabolites of diverse chemical classes have been reported from Agave species. Owing to their pharmacological significance, the steroidal saponins of Agave have caught the attention of phytochemists, biologists and drug discovery scientists. The present review describes 141 steroidal saponins and sapogenins and covers the literature published from 1970 to 2015. It is a comprehensive and coherent presentation of the structures, methods of chemical profiling, structure elucidation and biological activities of the saponins and sapogenins reported from Agave . The article provides a perspective of the research on steroidal compounds of Agave . Graphical abstract: A comprehensive description of the sapogenins and saponins of Agave species, their structural peculiarities, methods of extraction, isolation and chemical profiling, spectroscopic properties and biological activities. Highlights: Agave plants are known for a wide spectrum of uses and applications. The chemistry and bioactivities of the steroidal saponins of Agave are reviewed. Isolation, chemical profiling, structure elucidation and bioactivities of saponins are described.