An Efficient Four‐Component Approach for the Synthesis of Novel 5‐Methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐ 1‐arylethyl)‐1H‐pyrazol‐3‐ol Derivatives and their Antibacterial Study. Issue 14 (9th September 2016)

• Record Type: Journal Article
• Authors: Muthineni, Narmada; Satish Kumar, Nandigama; Chandrasekhara Rao, L.; Dileep Kumar, V.; Misra, Sunil; Raju Chowhan, L.; Meshram, H. M.
• Is Part Of: ChemistrySelect. Volume 1:Issue 14(2016)
• Page Start: 4197
• Page End: 4202
• Publication Date: 2016-09-09
• Subjects: Anti-bacterial -- 3, 5-dimethyl-4-nitroisoxazole -- Efficient -- Multi-component reactions (MCRs) -- Pyrazolone; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201600915
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A One pot four‐component domino reactions were developed for the synthesis of 5‐methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐1‐arylethyl)‐1H‐pyrazol‐3‐ols derivatives in excellent yield from hydrazine hydrate (1 ), ethyl acetoacetate (2 ), aldehyde (3 ) and 3, 5‐dimethyl‐4‐nitro‐isoxazole (4 ) using 10 mol% of piperidine. This method is simple, efficient and multiple bonds were generated (two C−C, one C−N, one O−H and one C=N) in a single step. These novel 5‐methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐1‐arylethyl)‐1H‐pyrazol‐3‐ol derivatives are evaluated as anti‐bacterial agents. Abstract : A One pot four‐component domino reactions were developed for the synthesis of 5‐methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐1‐arylethyl)‐1H‐pyrazol‐3‐ols derivatives in excellent yield from hydrazine hydrate (1 ), ethyl acetoacetate (2 ), aldehyde (3 ) and 3, 5‐dimethyl‐4‐nitro‐isoxazole (4 ) using 10 mol% of piperidine. This method is simple, efficient and multiple bonds were generated (two C−C, one C−N, one O−H and one C=N) in a single step. These novel 5‐methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐1‐arylethyl)‐1H‐pyrazol‐3‐ol derivatives are evaluated as anti‐bacterial agents