Elevated placenta growth factor levels in the early second-trimester amniotic fluid are associated with preterm delivery. (17th October 2016)

• Record Type: Journal Article
• Authors: Lee, Hambak; Kwon, Ji Young; Lee, Seungok; Kim, Sa Jin; Shin, Jong Chul; Park, In Yang
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 29:Number 20(2016)
• Page Start: 3374
• Page End: 3378
• Publication Date: 2016-10-17
• Subjects: Amniotic fluid -- angiogenic factors -- placenta growth factor -- preterm delivery; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2015.1127345
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective : The purpose of this study was to determine how angiogenesis-related factors correlate with preterm delivery. Methods : A cohort of 382 pregnant women undergoing early second-trimester genetic amniocentesis was enrolled and followed-up until delivery, and the amniotic fluid was collected and stored as a nested case-control study. Cases with preterm delivery ( n = 31) were compared with matched controls with term delivery ( n = 62). The amniotic fluid concentrations of placenta growth factor (PlGF), angiogenins, angiopoietin-2, soluble fms-like tyrosine kinase and soluble endoglin were determined using enzyme-linked immunosorbent assays. Results : Women who delivered preterm had a higher amniotic PlGF concentration compared with the control group (median 12.6 pg/ml versus 6.1 pg/ml; p =0.027). Other angiogenesis-related factors did not show any differences between case and control groups. The odds ratio for preterm delivery based on amniotic fluid PlGF was 1.031 (95% confidence interval: 1.002–1.061; p =0.035). Additionally, when the cases were subdivided into early preterm, late preterm and term groups, PlGF values between the early preterm and term delivery groups were significantly different (median 16.6 pg/ml versus 6.1 pg/ml; Bonferroni-adjusted p =0.018). Conclusion : Amniotic fluid PlGF levels in the early second trimester of pregnancy are associated with preterm delivery.