CD36 deficiency among South‐East Asian populations. (June 2016)

• Record Type: Journal Article
• Authors: Xia, W.; Xu, X.; Fu, Y.; Ye, X.; Tsuno, N.; Santoso, S.
• Is Part Of: ISBT science series. Volume 11(2016)Supplement 2
• Page Start: 33
• Page End: 36
• Publication Date: 2016-06
• Subjects: platelet antigens -- CD36 -- CD36 deficiency; Blood -- Periodicals; Blood -- Transfusion -- Periodicals; Immunohematology -- Periodicals; Immunopathology -- Periodicals; 615.39
• DOI: 10.1111/voxs.12261
• Languages: English
• ISSNs: 1751-2816

Abstract

Abstract : Immune‐mediated thrombocytopenia is commonly caused by platelet‐reactive antibodies mostly against polymorphic structures residing on platelet glycoproteins such as human leucocyte antigen and human platelet antigen (HLA class I and HPA). In the Japanese population, some individuals do not express CD36 (CD36 null also known as Nak a ) on the cell surface. Immunization of these individuals can lead to the development of CD36 iso antibodies (anti‐Nak a ) which play a role in the mechanism of platelet transfusion refractoriness, post‐transfusion purpura and fetal/neonatal alloimmune thrombocytopenia. Until today, however, little is known about the clinical relevance of CD36 deficiency and CD36 iso antibodies among other South‐East Asian populations. Therefore, multinational study was organised under the aegis of the ISBT to study the distribution of CD36 deficiency in this region.