Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome. (15th September 2016)

• Record Type: Journal Article
• Authors: Di Pietro, Mariana; Scotti, Leopoldina; Irusta, Griselda; Tesone, Marta; Parborell, Fernanda; Abramovich, Dalhia
• Is Part Of: Molecular and cellular endocrinology. Volume 433(2016)
• Page Start: 47
• Page End: 55
• Publication Date: 2016-09-15
• Subjects: Polycystic ovary syndrome -- Platelet derived growth factor -- Angiogenesis -- Ovary; PDGF Platelet Derived Growth Factor -- PCOS Polycystic Ovary Syndrome -- VEGF Vascular Endothelial Growth Factor -- OHSS Ovarian Hyperstimulation Syndrome -- ANGPT Angiopoietin -- TGFβ Transforming Growth Factor beta -- AMH Anti-Müllerian Hormone -- DHEA Dehydroepiandrosetrone -- FLK1 Fetal Liver Kinase 1; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2016.05.022
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Alterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased in follicular fluid of PCOS patients and in the ovaries of a rat model of PCOS. In the present study, we aimed to analyze the effects of local administration of PDGFB on ovarian angiogenesis, follicular development and ovulation in a DHEA-induced PCOS rat model. Ovarian PDGFB administration to PCOS rats partially restored follicular development, decreased the percentage of cysts, increased the percentage of corpora lutea, and decreased the production of anti-Müllerian hormone. In addition, PDGFB administration improved ovarian angiogenesis by reversing the increase in periendothelial cell area and restoring VEGF levels. Our results shed light into the mechanisms that lead to altered ovarian function in PCOS and provide new data for potential therapeutic strategies. Highlights: Ovarian PDGFB administration to PCOS rats improves follicular development. Local PDGFB administration to PCOS rats improves ovarian angiogenesis. PDGFB may be a potential new therapeutic and/or diagnosis strategy in PCOS.