Function and regulation of the Arp2/3 complex during cell migration in diverse environments. (October 2016)

• Record Type: Journal Article
• Authors: Swaney, Kristen F; Li, Rong
• Is Part Of: Current opinion in cell biology. Volume 42(2016)
• Page Start: 63
• Page End: 72
• Publication Date: 2016-10
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2016.04.005
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract : As the first de novo actin nucleator discovered, the Arp2/3 complex has been a central player in models of protrusive force production via the dynamic actin network. Here, we review recent studies on the functional role of the Arp2/3 complex in the migration of diverse cell types in different migratory environments. These findings have revealed an unexpected level of plasticity, both in how cells rely on the Arp2/3 complex for migration and other physiological functions and in the intricate modulation of the Arp2/3 complex by other actin regulators and upstream signaling cascades.