Nickel‐Catalyzed Carboxylation of Benzylic C−N Bonds with CO2. Issue 16 (16th March 2016)

• Record Type: Journal Article
• Authors: Moragas, Toni; Gaydou, Morgane; Martin, Ruben
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 16(2016)
• Page Start: 5053
• Page End: 5057
• Publication Date: 2016-03-16
• Subjects: carboxylation -- C−N activation -- homogeneous catalysis -- nickel -- reductive coupling; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201600697
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A user‐friendly Ni‐catalyzed reductive carboxylation of benzylic C−N bonds with CO2 is described. This procedure outperforms state‐of‐the‐art techniques for the carboxylation of benzyl electrophiles by avoiding commonly observed parasitic pathways, such as homodimerization or β‐hydride elimination, thus leading to new knowledge in cross‐electrophile reactions. Abstract : A user‐friendly method for the Ni‐catalyzed reductive carboxylation of benzylic C(sp 3 )−N bonds with CO2 is described. This new procedure outperforms state‐of‐the‐art techniques for the carboxylation of benzyl electrophiles by avoiding commonly observed parasitic pathways, such as homodimerization or β‐hydride elimination.