A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells. Issue 44 (12th May 2016)

• Record Type: Journal Article
• Authors: Kim, Hye-Ri; Kumar, Rajesh; Kim, Woori; Lee, Jae Hong; Suh, Myungkoo; Sharma, Amit; Kim, Chang Hoe; Kang, Chulhun; Seung Kim, Jong
• Is Part Of: Chemical communications. Volume 52:Issue 44(2016)
• Page Start: 7134
• Page End: 7137
• Publication Date: 2016-05-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc02330d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Herein, we report a highly selective, far-red, photo- and bio-stable fluorescent marker for the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells. Abstract : Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.