Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects. (October 2016)

• Record Type: Journal Article
• Authors: Öcal, Serpil; Portakal, Oytun; Öcal, Arslan; Demir, Ahmet Uğur; Topeli, Arzu; Çöplü, Lütfi
• Is Part Of: Respiratory medicine. Volume 119(2016)
• Page Start: 109
• Page End: 114
• Publication Date: 2016-10
• Subjects: Bronchiectasis -- Pulmonary hypertension -- Dyspnea -- Survival -- Endothelin-1 -- Hypoxemia; PH pulmonary hypertension -- HRCT high resolution computed tomography -- MRC Medical Research Council -- COPD chronic obstructive pulmonary disease -- ET-1 endothelin-1 -- BMI body mass index -- LV Left ventricular -- LVEF Left ventricular ejection fraction -- RV right ventricular -- RVEF right ventricular ejection fraction -- RVE right ventricular early diastolic velocity -- RVA right ventricular late diastolic velocity -- RVS right ventricular systolic velocity -- RVIVV right ventricular velocity during isovolumic contraction -- RVIVA right ventricular acceleration during isovolumic contraction -- TAPSE tricuspid annular plane systolic excursion -- sPAP systolic pulmonary artery pressure; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2016.08.027
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Background: The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. Methods: We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers. Results: Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P < 0.001 and P < 0.001, respectively). At three years, the survival rate was 95.7% for bronchiectasis subjects without PH and 56.3% for bronchiectasis with PH, and at 5 years, these rates were 95.7% and 62.5%, respectively (P = 0.002). Multivariate Cox regression analysis revealed that only the Medical Research Council (MRC) dyspnea score was independently related to poor survival in all bronchiectasis subjects (hazard ratio: 6.98; 95% CI: 2.41–20.23; P < 0.00001). Conclusions: Subjects with PH are more hypoxemic and have a greater number of involvements in the lobes of the lungs. Bronchiectasis subjects with PH have worse survival than do bronchiectasis subjects without PH. MRC dyspnea score is an independent predictor of long-term survival.