Prenylflavone derivatives from the seeds of Psoralea corylifolia exhibited PPAR-γ agonist activity. (June 2016)

• Record Type: Journal Article
• Authors: Ma, Shunan; Huang, Youwu; Zhao, Yuanyuan; Du, Guoxin; Feng, Li; Huang, Cheng; Li, Yiming; Guo, Fujiang
• Is Part Of: Phytochemistry letters. Volume 16(2016:Jun.)
• Page Start: 213
• Page End: 218
• Publication Date: 2016-06
• Subjects: Psoralea corylifolia -- Prenylflavone -- PPAR-γ -- Structure-activity relationship -- Diabetes; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.04.016
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: 22 prenylated flavonoids were isolated from the seeds of Psoralea corylifolia . Structures of three new compounds were elucidated. The agonistic activity for PPAR γ of 22 compounds was assayed. Abstract: Three new prenylflavones 2( R, S )-4′-hydroxy-6, 7-[2-(1-methoxy-1-methylethyl)-furano]-flavanone (1 ), 4′, 7-dihydroxy-3′, 5′-diprenyl-isoflavone (2 ) and 3, 4′, 7-trihydroxy-2-methoxy-3′-geranyl-isoflavanone (3 ), as well as 19 known ones were isolated and identified from the seeds of Psoralea corylifolia . In total, 22 prenylated molecules, including flavanones, isoflavones and chalcones analogues, were screened on the PPAR- γ agonist activity and their structure-activity relationship was also discussed.