Dianthus erinaceus var. erinaceus: Extraction, isolation, characterization and antimicrobial activity investigation of novel saponins. (June 2016)

• Record Type: Journal Article
• Authors: Mutlu, Kiymet; Sarikahya, Nazli Boke; Yasa, Ihsan; Kirmizigul, Suheyla
• Is Part Of: Phytochemistry letters. Volume 16(2016:Jun.)
• Page Start: 219
• Page End: 224
• Publication Date: 2016-06
• Subjects: Dianoside A (PubChem CID: 441919) -- Chionaeoside A (PubChem CID: 24179855) -- Chionaeoside B (PubChem CID: 101451751) -- Lucynoside E (PubChem CID: 13518126); Dianthus erinaceus -- Dianoside K -- Dianoside L -- Triterpenoid saponin -- Caryophyllaceae -- Antimicrobial activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.04.020
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new saponins, dianosides K–L, were isolated from Dianthus erinaceus var. erinaceus . All isolated compounds were identified by 1D-, 2D-NMR and HR-Mass techniques. Antimicrobial potential of dianosides K–L was tested by MIC method. Abstract: A phytochemical analysis of Dianthus erinaceus Boiss. var. erinaceus (Caryophyllaceae) has led to the isolation of two novel triterpenoid saponins, containing an oleane type skeleton, named dianosides K and L (1, 2), along with six known triterpenoid saponins (3–8). On the basis of chemical and spectrometric data, the structures of the new compounds were elucidated as 3- O -[β-d -glucopyranosyl (1 → 3)]–[β-d -glucopyranosyl (1 → 6)]-β-d -glucopyranosyl-olean-12-ene-23α, 28-β–dioic acid 28- O -β-d -glucopyranosyl ester (1) and 3- O -[β-d -glucopyranosyl (1 → 3)]–[β-d -glucopyranosyl(1 → 6)]-β-d -glucopyranosyl-olean-12-ene-23α, 28-β-dioic acid 28- O -α-l -mannopyranosyl (1 → 6)-β-d -glucopyranosyl ester (2). All isolated natural compounds were structurally characterized by 1D- ( 1 H, 13 C, DEPT); 2D- (COSY, HMQC, HMBC) NMR and HR-ESI/MS methods. The antimicrobial activity of compounds 1 and 2 were tested against four Gram-negative, three Gram-positive bacteria and the yeast Candida albicans by the MIC method.