Age-related differences in the neural correlates of trial-to-trial variations of reaction time. (June 2016)

• Record Type: Journal Article
• Authors: Adleman, Nancy E.; Chen, Gang; Reynolds, Richard C.; Frackman, Anna; Razdan, Varun; Weissman, Daniel H.; Pine, Daniel S.; Leibenluft, Ellen
• Is Part Of: Developmental cognitive neuroscience. Volume 19(2016)
• Page Start: 248
• Page End: 257
• Publication Date: 2016-06
• Subjects: ISVRT Intra-subject variation in reaction time -- RT-BOLD relationship change in the Blood Oxygenation Level Dependent signal associated with 1 s increase in reaction time; Reaction time -- Variation -- fMRI -- Development -- RT-BOLD; Cognitive neuroscience -- Periodicals; Developmental neurobiology -- Periodicals; Neuropsychology -- Periodicals; Neuropsychiatry -- Periodicals; 612.8233
• DOI: 10.1016/j.dcn.2016.05.001
• Languages: English
• ISSNs: 1878-9293

Abstract

Abstract: Intra-subject variation in reaction time (ISVRT) is a developmentally-important phenomenon that decreases from childhood through young adulthood in parallel with the development of executive functions and networks. Prior work has shown a significant association between trial-by-trial variations in reaction time (RT) and trial-by-trial variations in brain activity as measured by the blood-oxygenated level-dependent (BOLD) response in functional magnetic resonance imaging (fMRI) studies. It remains unclear, however, whether such "RT-BOLD" relationships vary with age. Here, we determined whether such trial-by-trial relationships vary with age in a cross-sectional design. We observed an association between age and RT-BOLD relationships in 11 clusters located in visual/occipital regions, frontal and parietal association cortex, precentral/postcentral gyrus, and thalamus. Some of these relationships were negative, reflecting increased BOLD associated with decreased RT, manifesting around the time of stimulus presentation and positive several seconds later. Critically for present purposes, all RT-BOLD relationships increased with age. Thus, RT-BOLD relationships may reflect robust, measurable changes in the brain-behavior relationship across development.