Biodegradable Dendronized Polymers for Efficient mRNA Delivery. Issue 15 (16th September 2016)

• Record Type: Journal Article
• Authors: Oldenhuis, Nathan J.; Eldredge, Alexander C.; Burts, Alan O.; Ryu, Keun Ah; Chung, Jae; Johnson, Mark E.; Guan, Zhibin
• Is Part Of: ChemistrySelect. Volume 1:Issue 15(2016)
• Page Start: 4413
• Page End: 4417
• Publication Date: 2016-09-16
• Subjects: Dendritic Cells -- Dendronized Polymers -- Gene Delivery -- Immune Cells -- mRNA Delivery; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201600939
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: As chemically modified messenger RNAs become less immunogenic and more stable against RNases, the need for synthetic vectors that can efficiently deliver mRNA into cells has increased significantly. Based on a dendronized polypeptide (denpol) architecture, we describe here the development of a synthetic vector system for efficient delivery of mRNAs. The optimized denpols show high efficiency of mRNA delivery to a variety of cells including primary murine dendritic cells (BMDCs), giving it potential use for anti‐tumor immunotherapy. Abstract : Based on a dendronized polypeptide (denpol) architecture, we describe here the development of a synthetic vector system for efficient delivery of mRNAs. The optimized denpols show high efficiency of mRNA delivery to a variety of cells including primary murine dendritic cells (BMDCs), giving it potential use for anti‐tumor immunotherapy.