Functionalizing the glycocalyx of living cells with supramolecular guest ligands for cucurbit[8]uril-mediated assembly. Issue 44 (12th May 2016)

• Record Type: Journal Article
• Authors: Cavatorta, Emanuela; Verheijden, Mark L.; van Roosmalen, Wies; Voskuhl, Jens; Huskens, Jurriaan; Jonkheijm, Pascal
• Is Part Of: Chemical communications. Volume 52:Issue 44(2016)
• Page Start: 7146
• Page End: 7149
• Publication Date: 2016-05-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc01693f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Metabolically presented naphthol ligands on the glycocalyx to trap cells to non-fouling lipid bilayers by heterocomplexation with cucurbit[8]uril and methylviologen. Abstract : Multiple naphthol ligands were installed on the glycocalyx of white blood cells via metabolic labeling and subsequent strain promoted azide–alkyne cycloaddition. Only when cucurbit[8]uril was present to drive the formation of ternary complexes, cells specifically assembled on a methylviologen functionalized supported lipid bilayer through multivalent interactions.