A de novo self-assembling peptide hydrogel biosensor with covalently immobilised DNA-recognising motifs. Issue 40 (27th April 2016)

• Record Type: Journal Article
• Authors: King, Patrick J. S.; Saiani, Alberto; Bichenkova, Elena V.; Miller, Aline F.
• Is Part Of: Chemical communications. Volume 52:Issue 40(2016)
• Page Start: 6697
• Page End: 6700
• Publication Date: 2016-04-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc01433j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The conjugate co-assemblies within the peptide-rich fibres leaving oligonucleotide recognition elements exposed on the external surface of the peptide fibre to ' fish out ' DNA/RNA sequences, leading to a fluorescence response. Abstract : We report here the first experimental evidence of a self-assembling three-dimensional (3D) peptide hydrogel, with recognition motifs immobilized on the surface of fibres capable of sequence-specific oligonucleotide detection. These systems have the potential to be further developed into diagnostic and prognostic tools in human pathophysiology.