Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration. (6th April 2016)

• Record Type: Journal Article
• Authors: Kamimura, Masao; Sugawara, Michiko; Yamamoto, Shota; Yamaguchi, Kazuo; Nakanishi, Jun
• Is Part Of: Biomaterials science. Volume 4:Number 6(2016:Jun.)
• Page Start: 933
• Page End: 937
• Publication Date: 2016-04-06
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/c6bm00100a
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : A photoactivatable gel substrate with defined mechanical properties was developed to study the mechanobiology of collective cell migration. Abstract : A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally controlled photo-irradiation of the substrate. The clusters exhibited unique collective motion that depended on substrate stiffness and cluster geometry.