Advances in diagnostics for transplant rejection. (2nd October 2016)

• Record Type: Journal Article
• Authors: Nasr, Michael; Sigdel, Tara; Sarwal, Minnie
• Is Part Of: Expert review of molecular diagnostics. Volume 16:Number 10(2016)
• Page Start: 1121
• Page End: 1132
• Publication Date: 2016-10-02
• Subjects: Molecular diagnostics -- acute rejection -- graft monitoring -- genomics -- transcriptomics -- proteomics -- personalized transplant management -- indicators of immune response -- organ transplantation; Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1080/14737159.2016.1239530
• Languages: English
• ISSNs: 1473-7159

Abstract

ABSTRACT: Introduction: Identification of allograft injury, including acute clinical and subclinical injury, is vital in increasing the longevity of the transplanted organ. Acute rejection, which occurs as a result of a variety of immune and non-immune factors including the infiltration of immune cells and antibodies to the donor specific epitopes, poses a significant risk to the organ. Recent years have marked an increase in the discovery of new genomic, transcriptomic, and proteomic biomarkers in molecular diagnostics, which offer better potential for personalized management of the transplanted organ by providing earlier detection of rejection episodes. Areas c overed: This review was compiled from key word searches of full-text publications relevant to the field. Expert c ommentary: Many of the recent advancements in the molecular diagnostics of allograft injury show much promise, but before they can be fully realized further validation in larger sample sets must be conducted. Additionally, for better informed therapeutic decisions, more work must be completed to differentiate between different causes of injury. Moreover, the diagnostics field is looking at methodologies that allow for multiplexing, the ability to identify multiple targets simultaneously, in order to provide more robust biomarkers and better understanding.