Effect of functionalization on drug delivery potential of carbon nanotubes. (16th November 2016)

• Record Type: Journal Article
• Authors: Sharma, Sonam; Mehra, Neelesh Kumar; Jain, Keerti; Jain, Narendra Kumar
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 44:Number 8(2016)
• Page Start: 1851
• Page End: 1860
• Publication Date: 2016-11-16
• Subjects: carbon nanotubes -- cellular trafficking -- characterization -- functionalization; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2015.1111227
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: The main aim of the present investigation was to explore the effect of functionalization on drug delivery potential of carbon nanotubes (CNTs) and to compare the in vitro and in vivo cancer targeting potential of doxorubicin HCL (DOX)-loaded ox- /multi-walled CNTs (MWCNTs), DOX-loaded PEG-MWCNTs and DOX-loaded FA-PEG-MWCNTs. The DOX/PEG-FA-MWCNTs showed enhanced cytotoxicity and were most preferentially taken up by the cancerous cells. The obtained results also support the extended resistance time and sustained release profile of drug-loaded surface-engineered MWCNTs. Overall, we concluded that the developed MWCNTs nanoformulations have higher cancer targeting potential.