Tuning the reactivity of Sp1 zinc fingers with platinum complexes. Issue 21 (12th May 2016)

• Record Type: Journal Article
• Authors: Du, Zhifeng; de Paiva, Raphael E. F.; Qu, Yun; Farrell, Nicholas
• Is Part Of: Dalton transactions. Volume 45:Issue 21(2016)
• Page Start: 8712
• Page End: 8716
• Publication Date: 2016-05-12
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c6dt01128d
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : The microenvironment around a zinc finger coordination unit affects the reactivity of apparently similar ZFs with Lewis acid platinum electrophiles. The unique dicysteine-bridged dinuclear platinum unit is the product of the reaction of [PtCl2 (en)] and the F3 of the transcription factor Sp1. Abstract : cis -DDP presents reactivity towards the transcription factor Sp1-F3, as opposed to previous observations for Sp1-F2. Replacing the ammine ligands with the chelating ethylenediamine increases the reactivity giving a unique dinuclear {Pt(en)}2 -bis(cysteine)-bridged product, confirmed by study of the binding sequence ACPECP.