The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer. Issue 22 (20th May 2016)

• Record Type: Journal Article
• Authors: Dou, Ruixia; Du, Zhen; Bao, Tao; Dong, Xinghua; Zheng, Xiaopeng; Yu, Miao; Yin, Wenyan; Dong, Binbin; Yan, Liang; Gu, Zhanjun
• Is Part Of: Nanoscale. Volume 8:Issue 22(2016)
• Page Start: 11531
• Page End: 11542
• Publication Date: 2016-05-20
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c6nr01543c
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : In this work, we developed a novel system for imaging-guided synergistic cancer therapy based on Bi2 S3 decorated graphene functionalized with polyvinylpyrrolidone. Abstract : Recently, a combination of chemotherapy with photothermal therapy (PTT) has received great attention for the construction of a near infrared (NIR)-controlled drug-delivery system for synergistic treatment of cancer, ultimately resulting in the enhancement of the therapeutic efficacy of anticancer drugs. Here, we developed a novel system for synergistic cancer therapy based on bismuth sulfide (Bi2 S3 ) nanoparticle-decorated graphene functionalized with polyvinylpyrrolidone (PVP) (named PVP-rGO/Bi2 S3 ). The as-prepared PVP-rGO/Bi2 S3 nanocomposite has a high storage capacity for anticancer drugs (∼500% for doxorubicin (DOX)) and simultaneously has perfect photothermal conversion efficiency in the NIR region. The results of the in vitro accumulative drug release test manifests that the PVP-rGO/Bi2 S3 nanocomposite could be applied as a dual pH- and NIR-responsive nanotherapeutic carrier for the controlled release of DOX from DOX-loaded PVP-rGO/Bi2 S3 (PVP-rGO/Bi2 S3 @DOX). Moreover, the treatment of both cancer cells (including Hela, MCF-7, HepG2 and BEL-7402 cells) and BEL-7402 tumor-bearing mice with the PVP-rGO/Bi2 S3 @DOX complex followed by NIR laser irradiation produces significantly greater inhibition of cancer cell growth than the treatment with NIR irradiation alone or DOX alone, exhibiting a synergistic antitumor effect. Furthermore, due to the obvious NIR and X-ray absorption ability, the PVP-rGO/Bi2 S3 nanocomposite could be employed as a dual-modal contrast agent for both photoacoustic tomography and X-ray computed tomography imaging. In addition to the good biocompatibility, the PVP-rGO/Bi2 S3 nanocomposite paves a potential way for the fabrication of theranostic agents for dual-modal imaging-guided chemo-photothermal combined cancer therapy.