Injectable shear-thinning nanoengineered hydrogels for stem cell delivery. Issue 24 (8th June 2016)
- Record Type:
- Journal Article
- Title:
- Injectable shear-thinning nanoengineered hydrogels for stem cell delivery. Issue 24 (8th June 2016)
- Main Title:
- Injectable shear-thinning nanoengineered hydrogels for stem cell delivery
- Authors:
- Thakur, Ashish
Jaiswal, Manish K.
Peak, Charles W.
Carrow, James K.
Gentry, James
Dolatshahi-Pirouz, Alireza
Gaharwar, Akhilesh K. - Abstract:
- Abstract : We report shear-thinning and injectable nanoengineered hydrogels loaded with two-dimensional (2D) nanosilicates and methacrylate kappa–carrageenan for cell-based therapies. Abstract : Injectable hydrogels are investigated for cell encapsulation and delivery as they can shield cells from high shear forces. One of the approaches to obtain injectable hydrogels is to reinforce polymeric networks with high aspect ratio nanoparticles such as two-dimensional (2D) nanomaterials. 2D nanomaterials are an emerging class of ultrathin materials with a high degree of anisotropy and they strongly interact with polymers resulting in the formation of shear-thinning hydrogels. Here, we present 2D nanosilicate reinforced kappa–carrageenan (κCA) hydrogels for cellular delivery. κCA is a natural polysaccharide that resembles native glycosaminoglycans and can form brittle hydrogels via ionic crosslinking. The chemical modification of κCA with photocrosslinkable methacrylate groups renders the formation of a covalently crosslinked network (MκCA). Reinforcing the MκCA with 2D nanosilicates results in shear-thinning characteristics, and enhanced mechanical stiffness, elastomeric properties, and physiological stability. The shear-thinning characteristics of nanocomposite hydrogels are investigated for human mesenchymal stem cell (hMSC) delivery. The hMSCs showed high cell viability after injection and encapsulated cells showed a circular morphology. The proposed shear-thinningAbstract : We report shear-thinning and injectable nanoengineered hydrogels loaded with two-dimensional (2D) nanosilicates and methacrylate kappa–carrageenan for cell-based therapies. Abstract : Injectable hydrogels are investigated for cell encapsulation and delivery as they can shield cells from high shear forces. One of the approaches to obtain injectable hydrogels is to reinforce polymeric networks with high aspect ratio nanoparticles such as two-dimensional (2D) nanomaterials. 2D nanomaterials are an emerging class of ultrathin materials with a high degree of anisotropy and they strongly interact with polymers resulting in the formation of shear-thinning hydrogels. Here, we present 2D nanosilicate reinforced kappa–carrageenan (κCA) hydrogels for cellular delivery. κCA is a natural polysaccharide that resembles native glycosaminoglycans and can form brittle hydrogels via ionic crosslinking. The chemical modification of κCA with photocrosslinkable methacrylate groups renders the formation of a covalently crosslinked network (MκCA). Reinforcing the MκCA with 2D nanosilicates results in shear-thinning characteristics, and enhanced mechanical stiffness, elastomeric properties, and physiological stability. The shear-thinning characteristics of nanocomposite hydrogels are investigated for human mesenchymal stem cell (hMSC) delivery. The hMSCs showed high cell viability after injection and encapsulated cells showed a circular morphology. The proposed shear-thinning nanoengineered hydrogels can be used for cell delivery for cartilage tissue regeneration and 3D bioprinting. … (more)
- Is Part Of:
- Nanoscale. Volume 8:Issue 24(2016)
- Journal:
- Nanoscale
- Issue:
- Volume 8:Issue 24(2016)
- Issue Display:
- Volume 8, Issue 24 (2016)
- Year:
- 2016
- Volume:
- 8
- Issue:
- 24
- Issue Sort Value:
- 2016-0008-0024-0000
- Page Start:
- 12362
- Page End:
- 12372
- Publication Date:
- 2016-06-08
- Subjects:
- Nanoscience -- Periodicals
Nanotechnology -- Periodicals
620.505 - Journal URLs:
- http://www.rsc.org/Publishing/Journals/NR/Index.asp ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6nr02299e ↗
- Languages:
- English
- ISSNs:
- 2040-3364
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 9830.266000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 2249.xml