Metal free C–H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1. Issue 18 (18th April 2016)

• Record Type: Journal Article
• Authors: Thatikonda, Thanusha; Singh, Umed; Ambala, Srinivas; Vishwakarma, Ram A.; Singh, Parvinder Pal
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 18(2016)
• Page Start: 4312
• Page End: 4320
• Publication Date: 2016-04-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob00526h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Here, we report a metal-free cross-coupling reaction of diazines and related heteroarenes with organoboron species. Abstract : Here, we report a metal-free cross-coupling reaction of diazines and related heteroarenes with organoboron species via C–H functionalization. The optimized conditions represent a metal-free method for the activation of aryl/heteroarylboronic acids, which undergo coupling with diazines and related heteroarenes. Optimized conditions also find application in the synthesis of a pyrimidine-based potent CDK inhibitor, meriolin 1 .