Glyco-copolypeptide grafted magnetic nanoparticles: the interplay between particle dispersion and RNA loading. Issue 19 (26th April 2016)

• Record Type: Journal Article
• Authors: Borase, T.; Fox, E. K.; Haddassi, Fadwa El; Cryan, S.-A.; Brougham, D. F.; Heise, A.
• Is Part Of: Polymer chemistry. Volume 7:Issue 19(2016)
• Page Start: 3221
• Page End: 3224
• Publication Date: 2016-04-26
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c6py00250a
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : Lysine-glyco-copolypeptide grafted superparamagnetic iron oxide nanoparticles were prepared through N -carboxyanhydride (NCA) copolymerization. Statistical and block copolymer arrangements were obtained while keeping the overal composition constant. Abstract : Lysine-glyco-copolypeptide grafted superparamagnetic iron oxide nanoparticles were prepared through N -carboxyanhydride (NCA) copolymerization. Statistical and block copolymer arrangements were obtained while keeping the overall composition constant. Both type of nanoparticles are fully water dispersible, which is key for T 1 -weighted magnetic resonance imaging (MRI) applications. A synergistic effect between siRNA loading and imaging properties was observed in the statistical copolymer arrangement allowed a significantly higher loading while retaining full particle dispersion, as required for T 1 -weighting.