Base-mediated regiospecific cascade synthesis of N-(2-pyridyl)pyrroles from N-propargylic β-enaminones. Issue 54 (18th May 2016)

• Record Type: Journal Article
• Authors: Shen, Jinhai; Yang, Xifa; Wang, Fuyuan; Wang, Yue; Cheng, Guolin; Cui, Xiuling
• Is Part Of: RSC advances. Volume 6:Issue 54(2016)
• Page Start: 48905
• Page End: 48909
• Publication Date: 2016-05-18
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra08987a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Two birds with one stone: two classical heterocycles, pyrrole and pyridine, were simultaneously installed from one acyclic enaminone precursor for the preparation of N -(2-pyridyl)pyrroles. Abstract : A KOH-promoted regiospecific synthesis of polysubstituted N -(2-pyridyl)pyrroles under transition metal-free conditions has been developed. The pyrrole and pyridine rings were simultaneously installed from acyclic enaminone precursors under mild conditions and generated 1 equiv. of H2 O as the sole byproduct. A series of polysubstituted N -(2-pyridyl)pyrroles were provided in up to 91% yield for 21 examples.