Carbon nanotube-mediated delivery of budesonide to macrophages. Issue 58 (1st June 2016)

• Record Type: Journal Article
• Authors: Foillard, Stéphanie; Russier, Julie; Seifert, Cécile; Dumortier, Hélène; Doris, Eric
• Is Part Of: RSC advances. Volume 6:Issue 58(2016)
• Page Start: 53282
• Page End: 53287
• Publication Date: 2016-06-01
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra09809f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A carbon nanotube-based carrier was developed for the delivery of anti-inflammatory budesonide to intracellular compartments of macrophages. Abstract : Carbon nanotubes were functionalized with budesonide, a potent anti-inflammatory drug, and investigated for interactions with macrophages. Pristine carbon nanotubes were first shortened to make them compatible with cellular dimensions before budesonide was non-covalently appended to their surface via a specifically designed amphiphilic molecule. The resulting nanohybrids were evaluated in regards to their internalisation into macrophages and ability to inhibit pro-inflammatory cytokine secretion. In vitro experiments showed that the budesonide delivery system is readily captured by phagocytic cells and has a deep anti-inflammatory effect as it strongly inhibits IL-6 production.