Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection. Issue 20 (5th May 2016)

• Record Type: Journal Article
• Authors: Afonso, Damien; Le Gall, Tony; Couthon-Gourvès, Hélène; Grélard, Axelle; Prakash, Shipra; Berchel, Mathieu; Kervarec, Nelly; Dufourc, Erick J.; Montier, Tristan; Jaffrès, Paul-Alain
• Is Part Of: Soft matter. Volume 12:Issue 20(2016)
• Page Start: 4516
• Page End: 4520
• Publication Date: 2016-05-05
• Subjects: Soft condensed matter -- Periodicals; 530.413
• DOI: 10.1039/c6sm00609d
• Languages: English
• ISSNs: 1744-683X

Abstract

Abstract : Thiol-ene reaction is applied to prepare branched cationic amphiphiles that are used for gene delivery. Abstract : The ramification of cationic amphiphiles on their unsaturated lipid chains is readily achieved by using the thiol–ene click reaction triggering the formation of an inverted hexagonal phase (HII ). The new ramified cationic lipids exhibit different bio-activities (transfection, toxicity) including higher transfection efficacies on 16HBE 14o-cell lines.