Target-triggered autonomous assembly of DNA polymer chains and its application in colorimetric nucleic acid detection. Issue 19 (5th April 2016)

• Record Type: Journal Article
• Authors: Dai, Jianyuan; He, Hongfei; Duan, Zhijuan; Zhou, Cuisong; Long, Yuyin; Zheng, Baozhan; Du, Juan; Guo, Yong; Xiao, Dan
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 19(2016)
• Page Start: 3191
• Page End: 3194
• Publication Date: 2016-04-05
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb00029k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : One-dimensional DNA polymer chains were obtained based on the catalyzed hairpin assembly and sticky end self-assembly, which led to a signal amplified colorimetric nucleic acid assay. Abstract : A novel target-triggered DNA autonomous assembly pathway for the formation of one-dimensional DNA polymer chains was proposed based on the catalyzed hairpin assembly and sticky end self-assembly, which led to an enzyme-free and signal amplified gold nanoparticle (AuNP) based colorimetric nucleic acid assay with picomolar sensitivity and specificity.