A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance. Issue 22 (16th May 2016)

• Record Type: Journal Article
• Authors: Liu, Juan; Ma, Xiaowei; Lei, Chunni; Xue, Xiangdong; Wei, Tuo; Zhao, Jing; Li, Shuyi; Liang, Xing-Jie
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 22(2016)
• Page Start: 3854
• Page End: 3858
• Publication Date: 2016-05-16
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb00761a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : The self-assembled DNA nanostructure was able to specifically target cancer cells and release the drug at pH 5.0. Abstract : We developed a novel self-assembled DNA nanostructure for anticancer drug delivery. The resulting nanostructure was able to specifically target cancer cells and release the loaded drug at pH 5.0. More importantly, the drug-loaded DNA nanostructure effectively circumvented doxorubicin resistance of human lung adenocarcinoma epithelial cancer cells.