Management of drug hypersensitivity in the pediatric population. Issue 10 (2nd October 2016)

• Record Type: Journal Article
• Authors: Atanaskovic-Markovic, Marina; Caubet, Jean-Christoph
• Is Part Of: Expert review of clinical pharmacology. Volume 9:Issue 10(2016)
• Page Start: 1341
• Page End: 1349
• Publication Date: 2016-10-02
• Subjects: Allergy -- β-lactam antibiotics -- children -- drug hypersensitivity -- drug provocation tests -- immediate reactions -- non-β-lactam antibiotics -- non-immediate reactions -- non-steroidal anti-inflammatory drugs -- skin tests; Clinical pharmacology -- Periodicals; 615.105
• DOI: 10.1080/17512433.2016.1213131
• Languages: English
• ISSNs: 1751-2433

Abstract

ABSTRACT: Introduction : Several recent studies confirmed that drug allergy in children is over diagnosed, which is a major public health problem, and results in use of alternative drugs, increasing resistance and health costs. Areas covered : Articles in English with data on drug hypersensitivity in children were identified by searching the databases of MEDLINE (National Library of Medicine) from 1990 till 2016. Expert commentary : It is crucial to make a precise diagnosis with performing a complete allergy work-up based on carefully selected diagnostic tests depending on whether an immediate or a non-immediate reaction is suspected. The drug provocation test remains the gold standard in diagnostic drug hypersensitivity in children.