The ENPP1 K121Q polymorphism is associated with type 2 diabetes and related metabolic phenotypes in a Taiwanese population. (15th September 2016)

• Record Type: Journal Article
• Authors: Hsiao, Tun-Jen; Lin, Eugene
• Is Part Of: Molecular and cellular endocrinology. Volume 433(2016)
• Page Start: 20
• Page End: 25
• Publication Date: 2016-09-15
• Subjects: Body mass index -- ENPP1 -- Metabolic phenotypes -- Obesity -- Single nucleotide polymorphisms -- Type 2 diabetes; ANOVA analysis of variance -- BMI body mass index -- CIs confidence intervals -- ORs Odds ratios -- ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -- SNP Single nucleotide polymorphism -- T2D type 2 diabetes; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2016.05.020
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Increased risk of developing type 2 diabetes (T2D) has been associated with a single nucleotide polymorphism (SNP), rs1044498 (K121Q), in the ectonucleotide pyrophosphatase/phosphodiesterase 1 ( ENPP1 ) gene, but this association is unclear among Asians. In this replication study, we reassessed whether the ENPP1 rs1044498 SNP is associated with T2D, obesity, and T2D/obesity-related metabolic traits in a Taiwanese population. A total of 1513 Taiwanese subjects were assessed in this study. The ENPP1 rs1044498 SNP was genotyped by the Taqman assay. T2D/Obesity-related quantitative traits, such as waist circumference and fasting glucose, were measured. Our data showed a significant association of the ENPP1 rs1044498 SNP with T2D (P < 0.001) among the subjects. Moreover, the ENPP1 rs1044498 SNP was significantly associated with T2D/obesity-related metabolic traits, such as waist circumference (P = 0.002) and fasting glucose (P < 0.001), among the subjects. However, we found no association of ENPP1 rs1044498 with obesity (BMI ≧ 27 kg/m 2 ). Our study indicates that the ENPP1 rs1044498 SNP is associated with T2D, waist circumference, and fasting glucose in Taiwanese subjects. Highlights: It is a key challenge to conduct reproducibility in genetic T2D and obesity research. This replication study was carried out in a Taiwanese population. The ENPP1 rs1044498 SNP may be linked with T2D. The ENPP1 rs1044498 SNP may predict waist circumference. The ENPP1 rs1044498 SNP may be associated with fasting glucose.