Toxin synergism in snake venoms. (1st October 2016)

• Record Type: Journal Article
• Authors: Laustsen, Andreas Hougaard
• Is Part Of: Toxin reviews. Volume 35:Number 3/4(2016)
• Page Start: 165
• Page End: 170
• Publication Date: 2016-10-01
• Subjects: Toxin synergism -- intermolecular synergism -- supramolecular synergism -- toxicity score -- snake venom -- snake toxins -- accumulated toxicity score; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2016.1220397
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: Synergism between venom toxins exists for a range of snake species. Synergism can be derived from both intermolecular interactions and supramolecular interactions between venom components, and can be the result of toxins targeting the same protein, biochemical pathway or physiological process. Few simple systematic tools and methods for determining the presence of synergism exist, but include co-administration of venom components and assessment of Accumulated Toxicity Scores. A better understanding of how to investigate synergism in snake venoms may help unravel strategies for developing novel therapies against snakebite envenoming by elucidating mechanisms for toxicity and interactions between venom components.