Brief Reports - Frequent BRAF or EGFR Mutations in Ciliated Muconodular Papillary Tumors of the Lung. Issue 2 (February 2016)

• Record Type: Journal Article
• Authors: Kamata, Tsugumasa; Sunami, Kuniko; Yoshida, Akihiko; Shiraishi, Kouya; Furuta, Koh; Shimada, Yoko; Katai, Hitoshi; Watanabe, Shun‐ichi; Asamura, Hisao; Kohno, Takashi; Tsuta, Koji
• Is Part Of: Journal of thoracic oncology. Volume 11:Issue 2(2016)
• Publication Date: 2016-02
• Subjects: BRAF -- Ciliated muconodular papillary tumors -- EGFR -- Histogenesis -- Next‐generation sequencing; Chest -- Cancer -- Periodicals; Thoracic Neoplasms -- Periodicals; 616.99494005
• DOI: 10.1016/j.jtho.2015.10.021
• Languages: English
• ISSNs: 1556-0864

Abstract

ABSTRACT: : Introduction: : Ciliated muconodular papillary tumors (CMPTs) are recently characterized, rare peripheral nodules of the lung. These small tumors are histologically comprised of a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, and consistently follow a benign clinical course. However, the histogenesis of CMPTs remains uncertain. Methods: : We performed detailed genomic analyses of 10 archived CMPT cases, using next‐generation sequencing and high‐resolution melting analysis. Results: : Mutations were identified in eight of the 10 cases (80%); four cases harbored the BRAF ‐V600E mutation, one case harbored the BRAF ‐G606R mutation, and three cases harbored deletions in exon 19 of EGFR . All of the deletions in EGFR were of the E746‐T751/S752V subtype. Conclusions: : The high prevalence of driver gene mutations in CMPTs supports the notion that these lesions are neoplastic rather than reactive or metaplastic.