Catechol-Bearing Polymeric Nanoparticles for Antioxidant Therapy. Issue 1797 (21st May 2015)

• Record Type: Journal Article
• Authors: Hasegawa, Urara; Moriyama, Masaki; Uyama, Hiroshi; van der Vlies, André J.; Metzger, Stéphanie; Ehrbar, Martin
• Editors: Xu, C.; Mitragotri, S.; Gu, Z.
• Is Part Of: MRS proceedings. Issue 1797(2015)
• Publication Date: 2015-05-21
• Subjects: polymer, -- nanostructure, -- biomaterial; Electrical engineering -- Congresses; Physics -- Congresses; Materials -- Research -- Congresses; Materials science -- Congresses; 620.11
• DOI: 10.1557/opl.2015.506
• Languages: English
• ISSNs: 0272-9172

Abstract

ABSTRACT: Polymeric nanoparticles having redox-active catechol moieties, a common structural motif found in naturally-occurring antioxidants, were developed. We synthesized an amphiphilic catechol-bearing polymer that self-assembled to form nanoparticles with a diameter of 126 nm. The nanoparticles showed enhanced ROS-scavenging activity compared to the small catecholic compound dopamine. Furthermore, the nanoparticles inhibited ROS-mediated angiogenesis as shown by the endothelial cell tube formation assay and the chicken chorioallantoic membrane (CAM) assay.