Characterization and cytotoxicity studies of thiol‐modified polystyrene microbeads doped with [{Mo6X8}(NO3)6]2– (X = Cl, Br, I)1. (11th January 2016)

• Record Type: Journal Article
• Authors: Vorotnikova, Natalya A.; Efremova, Olga A.; Tsygankova, Alphiya R.; Brylev, Konstantin A.; Edeleva, Mariya V.; Kurskaya, Olga. G.; Sutherland, Andrew J.; Shestopalov, Alexandr M.; Mironov, Yuri V.; Shestopalov, Michael A.
• Is Part Of: Polymers for advanced technologies. Volume 27:Number 7(2016)
• Page Start: 922
• Page End: 928
• Publication Date: 2016-01-11
• Subjects: molybdenum cluster complex -- photoluminescence -- polystyrene microbeads -- cytotoxicity; Polymers -- Periodicals; 668.9
• DOI: 10.1002/pat.3749
• Languages: English
• ISSNs: 1042-7147

Abstract

Abstract : Halide octahedral molybdenum clusters [{Mo6 X8 }L6 ] n– possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol‐modified polystyrene microbeads (PS‐SH) doped with [{Mo6 X8 }(NO3 )6 ] 2– (X = Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of {Mo6 I8 }@PS‐SH is significantly higher (0.04) than that of {Mo6 Cl8 }@PS‐SH (<0.005) and {Mo6 Br8 }@PS‐SH (<0.005). Treatment of Hep2 cells with {Mo6 X8 }@PS‐SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells. Copyright © 2016 John Wiley & Sons, Ltd.