C1. Maternal hemodynamic profile in hypertensive disorders of pregnancy (HDP) and intrauterine growth restriction. (12th August 2016)

• Record Type: Journal Article
• Authors: Di Martino, D.; Zullino, S.; Casati, D.; Grimaldi, A. S.; Mastroianni, C.; Principato, G.; Rosti, E.; Garbin, M.; Ferrazzi, E.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 29(2016)Supplement 2
• Page Start: 11
• Page End: 11
• Publication Date: 2016-08-12
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2016.1234771
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Aims : To investigate maternal hemodynamic status in pregnancies complicated by HDP and/or IUGR and by severe IUGR without HDP. Methods : In this prospective study we enrolled pregnant women between 24 and 38 weeks divided in: HDP with appropriate for gestational age fetuses (HDP-AGA), HDP associated with IUGR (HDPIUGR), severe IUGR and a group of controls matched for gestational age. Severe IUGR was defined as abdominal circumference <5th centile and a Doppler velocimetry in umbilical artery42SD. Diagnosis of HDP was made according to the criteria of the ISSHP. A cardiologist performed maternal echocardiographies to calculate cardiac output (CO), total vascular resistance (TVR) and indexes of diastolic dysfunction evaluated with tissue Doppler (E'/A'). Results : We recruited 16 HDP-AGA, 20 HDP-IUGR, 14 severe IUGR and 19 controls. Heart rate (HR) and CO were significantly decreased and TVR significantly increased in HDP-IUGR and severe IUGR compared to controls. HDP-AGA shows a significantly decrease in E0/A0 compared to all other groups. Discussion : Hemodynamic parameters have different patterns in pregnancies complicated by HDP and/or IUGR. Severe IUGR and HDP-IUGR show a similar profile, despite the absence of abnormal blood pressure in the former group. HDP-AGA, that in our data showed a maternal predisposition to metabolic syndrome, has a different hemodynamic profile, with a predominant diastolic dysfunction respect to the group of HDP-IUGR.