Immunoregulatory functions of immune complexes in vaccine and therapy. Issue 10 (29th August 2016)

• Record Type: Journal Article
• Authors: Wen, Yu‐mei; Mu, Libing; Shi, Yan
• Is Part Of: EMBO molecular medicine. Volume 8:Issue 10(2016)
• Page Start: 1120
• Page End: 1133
• Publication Date: 2016-08-29
• Subjects: adjuvant -- FcγR -- immune complex -- immune therapy -- vaccine; Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.15252/emmm.201606593
• Languages: English
• ISSNs: 1757-4676

Abstract

Abstract: Clinical and experimental preparations of IgG/soluble antigen complexes, as well as those formed following antibody therapy in vivo, are multifaceted immune regulators. These immune complexes (ICs) have been tested in humans and animal models, mostly in forms of experimental or clinical vaccination, for at least a century. With intensified research on Fcγ receptor‐mediated immune modulation, as well as with immune complex‐directed antigen processing, presentation, and inflammatory responses, there are renewed interests of using ICs in vaccines and immunotherapies. Currently, IC‐based immune therapy has been broadly experimented in HBV and HIV viral infection control and antitumor treatments. However, mechanistic insights of IC‐based treatments are relatively recent subjects of study; strong efforts are needed to establish links to connect laboratory findings with clinical practices. This review covers the history, mechanisms, and in vivo outcomes of this safe and effective therapeutic tool, with a clear aim to bridge laboratory findings with evolving clinical applications. Abstract : This review aims to provide a utilitarian look on immune complexes (ICs) from a perspective of clinical application, to complement the current picture of antibody immune therapy.