Novel role of p73 as a regulator of developmental angiogenesis: implication for cancer therapy. (2nd January 2016)

• Record Type: Journal Article
• Authors: Marin, Maria C; Marques, Margarita M
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 1(2016)
• Publication Date: 2016-01-02
• Subjects: angiogenesis -- endothelial cell differentiation -- endothelial cell migration -- induced pluripotent stem cells -- mouse embryonic stem cells -- p73 -- TGF-β -- vasculogenesis; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2015.1019973
• Languages: English
• ISSNs: 2372-3556

Abstract

Abstract : Information regarding the role of p73 in the regulation of angiogenesis has been incomplete and quite controversial. Remarkably, several groups, including ours, have recently demonstrated that TP73 plays a fundamental role in angiogenesis regulation and that differential expression of TP73 could have important consequences in tumor angiogenesis. Here, we discuss a possible model for p73 function in the regulation of developmental angiogenesis and tumor angiogenesis.