A novel oxaphenalenone, penicimutalidine: activated production of oxaphenalenones by the diethyl sulphate mutagenesis of marine-derived fungus Penicillium purpurogenum G59. Issue 85 (30th August 2016)

• Record Type: Journal Article
• Authors: Li, Chang-Wei; Xia, Ming-Wen; Cui, Cheng-Bin; Peng, Ji-Xing; Li, De-Hai
• Is Part Of: RSC advances. Volume 6:Issue 85(2016)
• Page Start: 82277
• Page End: 82281
• Publication Date: 2016-08-30
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra17087k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : One new (1 ) and three known oxaphenalenones (2–4 ) were obtained by activating silent pathways in a marine-derived fungus. Abstract : A novel oxaphenalenone, penicimutalidine (1 ), was isolated from a fungal mutant generated through the diethyl sulfate (DES) mutagenesis of marine-derived Penicillium purpurogenum G59 along with three known oxaphenalenones (2–4 ). The structure of1, including the absolute configuration, was determined by spectroscopic methods, including TDDFT electronic CD calculations. HPLC-UV/HPLC-MS analyses verified that1–4 were only produced in the mutant through the activation of silent biosynthetic pathways in the parent strain by DES mutagenesis.