Investigation of the ototoxicity of gadoteridol (ProHance) and gadodiamide (Omniscan) in mice. (1st November 2016)

• Record Type: Journal Article
• Authors: Nonoyama, Hiroshi; Tanigawa, Tohru; Shibata, Rei; Tanaka, Hirokazu; Katahira, Nobuyuki; Horibe, Yuichiro; Takemura, Keiji; Murotani, Kenta; Ozeki, Norio; Ueda, Hiromi
• Is Part Of: Acta oto-laryngologica. Volume 136:Number 11(2016)
• Page Start: 1091
• Page End: 1096
• Publication Date: 2016-11-01
• Subjects: Auditory brainstem response -- gadolinium-based contrast agent -- gadoteridol -- gadodiamide -- MRI -- mouse -- ototoxicity -- surface preparation; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2016.1193892
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Conclusion: In the mouse, when a tympanic perforation is present, gadoteridol does not seem to cause ototoxicity. Gadodiamide may cause mild ototoxicity other than toxicity to the outer hair cells of the cochlea. Objectives: Endolymphatic hydrops have been visualized through intra-tympanic injection of gadolinium-based contrast agents (GBCAs) and three-dimensional fluid-attenuated inversion recovery (3-D FLAIR) magnetic resonance imaging. However, reports on the safety of GBCAs are limited. This study aimed to assess ototoxicity of gadoteridol and gadodiamide. Method: In a prospective, randomized, controlled trial, myringotomies in the left ear were performed in 20 male C57 BL/6 mice. After testing the baseline auditory brainstem response (ABR) (range = 8–32 kHz), the test solution (gadoteridol, gadodiamide, saline, or cisplatin) was injected into the left ear. ABR testing was repeated 14 days after test solution application. In morphological experiments, images of post-mortem surface preparations were assessed for cochlear hair cell status. Results: At 14 days following gadoteridol application, there was no significant change in ABR thresholds at 8, 16, or 32 kHz. Gadodiamide application caused a significant change in the ABR threshold at 8 kHz. Apparent cochlear hair cell loss was not observed in the surface preparation after gadoteridol or gadodiamide application.