Efficient and Targeted Suppression of Human Lung Tumor Xenografts in Mice with Methotrexate Sodium Encapsulated in All‐Function‐in‐One Chimeric Polymersomes. Issue 37 (6th July 2016)

• Record Type: Journal Article
• Authors: Yang, Weijing; Zou, Yan; Meng, Fenghua; Zhang, Jian; Cheng, Ru; Deng, Chao; Zhong, Zhiyuan
• Is Part Of: Advanced materials. Volume 28:Issue 37(2016)
• Page Start: 8234
• Page End: 8239
• Publication Date: 2016-07-06
• Subjects: lung cancer -- methotrexate sodium -- polymersomes -- reduction‐sensitive -- targeted delivery; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201600065
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Anisamide‐functionalized reversibly crosslinked chimeric polymersomes emerge as an "all‐function‐in‐one" nanoplatform for efficient loading and targeted delivery of methotrexate disodium, a potent water‐soluble anticancer drug, to sigma receptor overexpressing H460 nonsmall lung cancer xenografts in vivo, leading to markedly improved tumor‐growth inhibition and survival rate and depleted adverse effects as compared to the clinically used formulation (Trexall).