ChemInform Abstract: Synthesis and anti‐HIV Activity of 5′‐Homo‐2′, 3′‐dideoxy‐2′, 3′‐didehydro‐4′‐selenonucleosides (5′‐Homo‐4′‐Se‐d4 Ns). Issue 43 (7th October 2016)

• Record Type: Journal Article
• Authors: Qu, Shuhao; Kim, Gyudong; Yu, Jinha; Sahu, Pramod K.; Choi, Yoojin; Naik, Siddhi D.; Jeong, Lak Shin
• Is Part Of: ChemInform. Volume 47:Issue 43(2016)
• Page Start: no
• Page End: no
• Publication Date: 2016-10-07
• Subjects: nucleic acids -- organo‐selenium compounds -- anti‐hiv activity; Chemistry -- Abstracts -- Periodicals; 540.5
• DOI: 10.1002/chin.201643179
• Languages: English
• ISSNs: 0931-7597

Abstract

Abstract: Starting from previously developed homoselenonucleosides such as (I), a short route to the title compounds (VII) is developed using the conversion of the diol unit to a thiocarbonyl protected diol and following diazaphospholidine mediated elimination as key steps.