Phytochemical and Pharmacological Investigations on Nymphoides indica Leaf Extracts. (10th June 2016)

• Record Type: Journal Article
• Authors: Amin, Adnan; Tuenter, Emmy; Exarchou, Vassiliki; Upadhyay, Atul; Cos, Paul; Maes, Louis; Apers, Sandra; Pieters, Luc
• Is Part Of: Phytotherapy research. Volume 30:Number 10(2016)
• Page Start: 1624
• Page End: 1633
• Publication Date: 2016-06-10
• Subjects: Nymphoides indica -- Menyanthaceae -- aquatic herb -- traditional medicine -- Pakistan; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.5663
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : Nymphoides indica (L.) Kuntze (Menyanthaceae) is traditionally used in the Indian subcontinent. However, scientific data reporting its constituents are poor. This study aimed at evaluating its phytochemical constituents and various biological activities. Phytochemical investigations of the extracts and fractions resulted in the isolation of 5 lipophilic compounds, i.e. azelaic (nonanedioic) acid (1) and 4‐methyl‐heptanedioic acid (3), hexadecanoic (2) and stearic acid (5) and the fatty alcohol hexadecanol (4); 3 seco‐iridoids, i.e. 7‐epiexaltoside (6), 6″, 7″‐dihydro‐7‐epiexaltoside (7) and menthiafolin (8); 3 flavonoids, i.e. 3, 7‐di‐ O ‐methylquercetin‐4′‐ O ‐β‐glucoside (9), 3‐ O ‐methylquercetin‐7‐ O ‐β‐glucoside (10) and 3, 7‐di‐ O ‐methylquercetin (11); scopoletin (12) and ferulic acid (13); and the monoterpenoids foliamenthoic acid (14) and 6, 7‐dihydrofoliamenthoic acid methyl ester (15). Compounds 1–5 showed moderate antimicrobial activities, whereas compound 9 presented mild antiprotozoal activities against Trypanosoma brucei (IC50 8 μM), Leishmania infantum (IC50 32 μM) and Trypanosoma cruzi (IC50 30 μM). Antiglycation activity was shown by compounds 7 (IC50 0.36 mM), 10 (IC50 0.42 mM) and 15 (IC50 0.61 mM). Finally α‐glucosidase inhibition was shown by compounds 7, 9, 11 and 13–15. It could be concluded that N . indica leaf extracts possess mild to moderate antimicrobial, antiprotozoal, antioxidant and antidiabetic activities. Copyright © 2016 John Wiley & Sons, Ltd.