Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates. (October 2016)

• Record Type: Journal Article
• Authors: Lewis, Brittany B.; Carter, Rebecca A.; Pamer, Eric G.
• Is Part Of: Anaerobe. Volume 41(2016)
• Page Start: 32
• Page End: 36
• Publication Date: 2016-10
• Subjects: Clostridium difficile -- Secondary bile acid; Anaerobic infections -- Periodicals; Anaerobic bacteria -- Periodicals; Bacterial diseases -- Periodicals; Computer network resources; Anaerobic protozoa -- Periodicals; 579.3
• DOI: 10.1016/j.anaerobe.2016.05.010
• Languages: English
• ISSNs: 1075-9964

Abstract

Abstract: Clostridium difficile is an anaerobic bacterium that causes diarrheal illnesses. Disease onset is linked with exposure to oral antibiotics and consequent depletion of secondary bile acids. Here we investigate the relationship between in vitro secondary bile acid tolerance and in vivo disease scores of diverse C. difficile strains in mice. Highlights: Clostridium difficile isolates collected from patients cause a range of disease in mice. These isolates exhibit variable tolerance to secondary bile acids in vitro . Tolerance to lithocholic acid is associated with higher disease scores in mice.