Adenosine triphosphate postconditioning is associated with better preserved global and regional cardiac function during myocardial ischemia and reperfusion: a speckle tracking imaging‐based echocardiologic study. Issue 5 (October 2016)

• Record Type: Journal Article
• Authors: Ren, Min; Liu, Yujie; Zhao, Huiya; Dong, Shixia; Jiang, Zhonghui; Li, Keting; Tian, Jiawei
• Is Part Of: Cardiovascular therapeutics. Volume 34:Issue 5(2016:Oct.)
• Page Start: 343
• Page End: 351
• Publication Date: 2016-10
• Subjects: Adenosine triphosphate -- Cardiac function -- Ischemia and reperfusion injury -- Postconditioning -- Speckle tracking imaging; Cardiovascular pharmacology -- Periodicals; Cardiovascular agents -- Periodicals; Cardiovascular system -- Diseases -- Chemotherapy -- Periodicals; Cardiovascular Agents -- Periodicals; Cardiovascular Diseases -- drug therapy -- Periodicals; Agents cardiovasculaires -- Périodiques; Appareil cardiovasculaire -- Maladies -- Chimiothérapie -- Périodiques; 616.1005
• DOI: 10.1111/1755-5922.12205
• Languages: English
• ISSNs: 1755-5914

Abstract

Summary: Introduction: Effects of ischemic postconditioning (IPostC) and adenosine triphosphate (ATP)‐mediated pharmacologic postconditioning (ATP‐PPostC) on cardiac function were evaluated by speckle tracking imaging (STI)‐based echocardiography. Aims: A myocardial I/R model was induced in rabbits by reversible ligation of the left ventricular branch of coronary artery. Rabbits were randomized into three groups: ischemia and reperfusion (IR) (no further intervention), IPostC, and ATP‐PPostC groups. Cardiac function was evaluated by conventional and STI‐based echocardiography. Myocardial necrosis, apoptosis, and myocardial mRNAs of apoptosis‐related proteins (Bcl‐2 and Bax) were evaluated. Results: Speckle tracking imaging (STI)‐based echocardiography revealed that IPostC and ATP‐PPostC were associated with better preserved global and regional cardiac function, as indicated by significantly increased GLSrsys, GLSrd, GLSsys, SrLsys, SrLd, and SLsys in both groups (all P <.5). Subsequent pathologic studies indicate that the percentage of necrotic myocardium and permillage of apoptotic cells were significantly lower in the IPostC and ATP‐PPostC groups than in the IR group (all P <.05). Moreover, both IPostC and ATP‐PPostC were associated with increased Bcl‐2 mRNA levels and reduced Bax mRNA levels. Conclusions: IPostC and ATP‐PPostC may exert cardioprotective functions by better preservation of cardiac function during the I/R process and at least partly via attenuation of myocardial apoptosis.