A Programmable Signaling Molecular Recognition Nanocavity Prepared by Molecular Imprinting and Post‐Imprinting Modifications. Issue 42 (6th October 2016)

• Record Type: Journal Article
• Authors: Horikawa, Ryo; Sunayama, Hirobumi; Kitayama, Yukiya; Takano, Eri; Takeuchi, Toshifumi
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 42(2016)
• Page Start: 13023
• Page End: 13027
• Publication Date: 2016-10-06
• Subjects: imprinting -- molecular recognition -- polymers -- proteins -- sensors; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201605992
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Inspired by biosystems, a process is proposed for preparing next‐generation artificial polymer receptors with molecular recognition abilities capable of programmable site‐directed modification following construction of nanocavities to provide multi‐functionality. The proposed strategy involves strictly regulated multi‐step chemical modifications: 1) fabrication of scaffolds by molecular imprinting for use as molecular recognition fields possessing reactive sites for further modifications at pre‐determined positions, and 2) conjugation of appropriate functional groups with the reactive sites by post‐imprinting modifications to develop programmed functionalizations designed prior to polymerization, allowing independent introduction of multiple functional groups. The proposed strategy holds promise as a reliable, affordable, and versatile approach, facilitating the emergence of polymer‐based artificial antibodies bearing desirable functions that are beyond those of natural antibodies. Abstract : Inspired by the process of post‐translational modifications in protein biosynthesis, a process for preparing next‐generation artificial polymer receptors with molecular recognition abilities is proposed. These receptors are capable of programmable site‐directed modification following construction of nanocavities to provide multi‐functionality.