An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives. Issue 19 (31st August 2016)

• Record Type: Journal Article
• Authors: Mocci, Rita; Luca, Lidia De; Delogu, Francesco; Porcheddu, Andrea
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 19(2016)
• Page Start: 3135
• Page End: 3144
• Publication Date: 2016-08-31
• Subjects: ball milling -- O, N-dialkyl hydroxamates -- hydroxamic acids -- mechanochemical activation -- mechanochemistry; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201600350
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An operationally simple, and cost efficient conversion of carboxylic acids into hydroxamic acid derivatives via a high‐energy mechanochemical activation is presented. This ball milling methodology was applied to a wide variety of carboxylic acids dramatically improving purification issues associated with this class of molecules, which still remain one of the main bottlenecks of classical methodologies. Abstract :