Cu-catalyzed sulfenylation of imidazol[1, 2-a]pyridine via C–H functionalization using a combination of Na2S2O3 and halides. Issue 85 (30th August 2016)

• Record Type: Journal Article
• Authors: Ding, Yingcai; Xie, Ping; Zhu, Wenhui; Xu, Baojun; Zhao, Wannian; Zhou, Aihua
• Is Part Of: RSC advances. Volume 6:Issue 85(2016)
• Page Start: 81932
• Page End: 81935
• Publication Date: 2016-08-30
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra18136h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A copper-catalysed sulfenylation of 2-phenylimidazo[1, 2- a ]pyridine by using inorganic salt Na2 S2 O3 and alkyl halides (Cl, Br, I) or iodobenzene homologues via C–H functionalization process was reported here. Abstract : A novel copper-catalysed sulfenylation method by using the inorganic salt Na2 S2 O3 and alkyl halides (Cl, Br, I) or iodobenzene homologues is described. The reactions proceeded smoothly, giving regioselective 2-phenylimidazo[1, 2- a ]pyridine thioether derivatives in good yields via a C–H functionalization process. More importantly, this method has extended the existing methods by offering a better method which can make both alkyl and aryl thioether derivatives under one set of reaction conditions.