GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses. Issue 36 (7th September 2016)

• Record Type: Journal Article
• Authors: Lee, Edward C.; Davis-Poynter, Nicholas; Nguyen, Chau T. H.; Peters, Amelia A.; Monteith, Gregory R.; Strounina, Ekaterina; Popat, Amirali; Ross, Benjamin P.
• Is Part Of: Nanoscale. Volume 8:Issue 36(2016)
• Page Start: 16192
• Page End: 16196
• Publication Date: 2016-09-07
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c6nr03878f
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Mesoporous and solid silica nanoparticles functionalised with a novel glycosaminoglycan (GAG) mimetic inhibit the cellular attachment and penetration of herpes simplex virus (HSV). Abstract : A glycosaminoglycan mimetic was attached to the surface of solid and mesoporous silica nanoparticles to create novel antiviral agents against herpes simplex type 1 and type 2 viruses. The nanoparticles act as viral entry inhibitors that appear to block viral attachment and penetration into susceptible cells.