Utility of the Montreal Cognitive Assessment as a Screening Test for Neurocognitive Dysfunction in Adults with Sickle Cell Disease. Issue 9 (September 2016)

• Record Type: Journal Article
• Authors: Cichowitz, Cody; Carroll, Patrick C.; Strouse, John J.; Haywood, Carlton; Lanzkron, Sophie
• Is Part Of: Southern medical journal. Volume 109:Issue 9(2016)
• Publication Date: 2016-09
• Subjects: cognitive impairment -- Montreal Cognitive Assessment -- screening -- sickle cell disease; Medicine -- Periodicals; 610.5
• DOI: 10.14423/SMJ.0000000000000511
• Languages: English
• ISSNs: 0038-4348

Abstract

Abstract : Objectives: Neurocognitive dysfunction is an important complication of sickle cell disease (SCD), but little is published on the utility of screening tests for cognitive impairment in people with the disease. The purpose of this study was to evaluate the Montreal Cognitive Assessment (MoCA) as a screening tool and identify predictors of MoCA performance in adults with sickle cell disease. Methods: We conducted a retrospective, cross-sectional study of the first 100 adult patients with SCD who completed the MoCA as part of routine clinical care at the Johns Hopkins Sickle Cell Center for Adults. We abstracted demographic, laboratory, and clinical data from each participant's electronic medical record up to the date that the MoCA was administered. The factorial validity of each MoCA domain was analyzed using standard psychometric statistics. We evaluated the abstracted data for associations with the composite MoCA score and looked for independent predictors of performance using multivariable regressions. Results: Components of the MoCA performed well in psychometric analyses and identified deficits in executive function that were described in other studies. Forty-six percent of participants fell below the cutoff for mild cognitive impairment. Increased education was an independent predictor of increased MoCA score (3.1, 95% confidence interval [CI] 1.5–4.7), whereas cerebrovascular accidents and chronic kidney disease were independent predictors of decreased score (−3.3, 95% CI −5.7 to −0.97 and −3.2, 95% CI −6.2 to −0.11, respectively). When analysis was restricted to patients with SCA, increased education (3.7, 95% CI 2.2–5.2) and a history of hydroxyurea therapy (2.0, 95% CI −0.022 to 4.0) were independent predictors of a higher score, whereas chronic kidney disease (−3.3, 95% CI −6.4 to −0.24) and increased aspartate transaminase (−0.045, 95% CI −0.089 to −0.0010) were independent predictors of a decreased score. Conclusions: The MoCA showed promise by identifying important cognitive deficits and associations with chronic complications and therapy. Abstract : The Montreal Cognitive Assessment was administered to adults with sickle cell disease to evaluate its utility as a screening tool for cognitive impairment and to identify predictors of neurocognitive dysfunction. The Assessment showed promise by identifying important cognitive deficits and associations with chronic complications and therapy.